BOSTON (AP) — Red Sox ace Chris Sale struck out a career-high 17 in just seven innings before getting pulled after 108 pitches on a chilly Tuesday night, and the Colorado Rockies rallied against Boston’s bullpen to win 5-4 in the 11th.

Sale became the first pitcher in major league history to fan 17 in a start of no more than seven innings. Boston pitchers combined to strike out 24, but the Red Sox had their five-game winning streak stopped.

Mark Reynolds, whose fifth-inning double was the first runner allowed by Sale, drove in the go-ahead run with a two-out single in the 11th off Ryan Brasier (2-2).

Sale struck out the first six batters and fanned eight through three innings. He topped his previous best of 15 strikeouts, which he had done three times. The All-Star lefty had a shutout through six innings. Nolan Arenado’s two-run homer in the seventh was one of only three hits managed by the Rockies against Sale.

Mike Dunn (1-0) got the win with one inning of scoreless relief and Wade Davis got his seventh save.

Charlie Blackmon also homered for the Rockies. Michael Chavis, J.D. Martinez and Rafael Devers homered for Boston.

Kyle Freeland got the start for Colorado on his 26th birthday and went six innings, allowing three runs on five hits, striking out seven and walking three.

Blue Jays 7, Giants 3

SAN FRANCISCO (AP) — Vladimir Guerrero Jr. homered twice to become the third-youngest player to hit his first two major league homers in the same game in Toronto’s victory over San Francisco.

Guerrero, who finished with three hits and four RBIs, became the youngest in franchise history to go deep as the Blue Jays won the opener of a six-game trip after losing five of six on a homestand in which they totaled eight runs.

Trent Thornton (1-4) pitched three-hit ball into the sixth inning for his first major league win. He struck out seven and overcame five walks.

The 20-year-old Guerrero homered in the first inning against Giants opener Nick Vincent (0-2). He added an even more impressive blast in the sixth off Reyes Moronta, a three-run drive estimated at 451 feet.

The only players younger than Guerrero to hit their first two home runs in the same game are Brian McCall in 1962 (19 years, 248 days) and Manny Machado in 2012 (20 years, 35 days).

Pablo Sandoval homered for San Francisco.

Twins 4, Angels 3

MINNEAPOLIS (AP) — Mitch Garver hit a two-run homer and tagged out Shohei Ohtani trying to score the tying run in the eighth inning before leaving with an injury, helping Minnesota hold off Los Angeles.

Garver hit his ninth homer in the third to give Minnesota a three-run lead behind Kyle Gibson (4-1). Byron Buxton added an RBI double the next inning, and five relievers combined for 3 1/3 scoreless innings, with Blake Parker getting his seventh save in seven chances.

Ohtani had three hits, including an RBI single as part of a three-run sixth, but he was thrown out at third base in the sixth and at home in the eighth after Brian Goodwin’s single to center.

The Twins lead the majors with 16 home runs and 38 RBIs from the catching position, also getting strong contributions from Castro and Willians Astudillo.

Cam Bedrosian (1-2) took the loss for Los Angeles, serving as the opener for primary pitcher Felix Peña. Bedrosian gave up one run and two hits in one inning.

Gibson cruised through five innings before running into trouble in the sixth. He allowed three runs, six hits and two walks in 5 2/3 innings.

Mariners 4, Athletics 3

SEATTLE (AP) — Daniel Vogelbach, Tim Beckham and Mitch Haniger homered and Roenis Elias pitched out of a bases-loaded jam in Seattle’s win over Oakland.

Haniger’s deep two-run shot into the second deck in left field in the fifth inning broke a 2-2 tie, and Elias stopped a bases-loaded threat with two outs in the seventh with a strikeout, as the Mariners sent the A’s to their third straight loss, and fourth in six games.

Mike Leake (3-4) gave up five hits and struck out six. He was chased after 6 2/3 innings when Oakland cut it to 4-3 on an RBI single by Robbie Grossman in the seventh inning.

A’s starter Brett Anderson (4-3) gave up just six hits and struck out five in six innings.

Astros 11, Tigers 4

DETROIT (AP) — Carlos Correa started another Houston onslaught with a three-run homer in the first inning, and the Astros routed Detroit, extending their winning streak to seven games.

The Astros, who have won 10 of 11, scored in each of the first six innings against a depleted Detroit pitching staff. George Springer hit an inside-the-park homer in the fifth, and Aledmys Diaz went deep in the third for Houston.

Wade Miley (4-2) allowed four runs in six innings for the Astros. Houston led 7-0 after its half of the third.

Ronny Rodriguez homered for Detroit. Ryan Carpenter (0-2) made his second start of the season and allowed seven earned runs in four innings.

Springer circled the bases in the fifth when his drive to right-center field bounced off the wall and past center fielder JaCoby Jones. It was the first inside-the-park home run of his career, and Houston led 9-2.

The Astros have scored 45 runs in their last four games.

Rays 4, Marlins 0

MIAMI (AP) — Charlie Morton pitched six strong innings and Avisail Garcia homered and drove in three runs in Tampa Bay’s win over Miami.

Morton (4-0) gave up three hits and struck out five while throwing 82 pitches before he was pulled for a pinch hitter in the top of the seventh inning.

Garcia had a solo homer and two RBI singles for the Rays in the opener of the two-game series against their cross-state interleague rivals. Garcia finished the scoring with an infield single with the bases loaded in the ninth.

Miami starter Caleb Smith (3-1) didn’t last past the sixth inning for the first time since his opening start on April 1. He allowed two runs and four hits, while striking out eight and walking two in 5 1/3 innings. The Marlins lost their sixth straight and ninth in the last 10.

Relievers Emilio Pagan, Diego Castillo and Chaz Roe pitched the final three innings for Tampa Bay.

Indians 9, White Sox 0

CHICAGO (AP) — Jordan Luplow hit two of Cleveland’s five homers and Carlos Carrasco cruised through seven innings in a rout of Chicago.

Roberto Pérez, Jake Bauers and José Ramirez also went deep as the light-hitting Indians muscled up against Manny Bañuelos and Josh Osich to end Chicago’s three-game winning streak.

The 25-year-old Luplow has hit all four of his homers this season against Chicago and three off Bañuelos.

Carrasco (4-3) scattered six singles and struck out six, while walking none, in his second straight solid start. Oliver Pérez, Dan Otero and A.J. Cole combined to complete the seven-hitter.

Bañuelos (2-3) yielded five runs on four hits and three walks before leaving the game with none out in the fifth with left shoulder soreness.

Royals 11, Rangers 5

KANSAS CITY, Mo. (AP) — Hunter Dozier drove in three runs, top prospect Nicky Lopez had an RBI single in his big league debut, and Kansas City routed Texas.

Alex Gordon and Jorge Soler also drove in two runs apiece for the Royals, who scored nine times in the first two innings while quickly knocking Rangers starter Shelby Miller from the game.

Danny Duffy (2-1) was only marginally better for Kansas City, using 107 pitches just to survive five innings. He allowed four runs, seven hits and a walk while striking out seven.

Miller (1-3) was pulled with two outs in the second after allowing eight runs and seven hits with two walks.

Rangers shortstop Elvis Andrus left with tightness in his right hamstring after grounding out to end the seventh inning. He will be evaluated again Wednesday.

Joey Gallo had a pair of RBIs for the Rangers, who stranded runners in four consecutive innings.

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